If it's possible, I think 2-way players are VERY underrated in this league. The fact that "best PG" conversations always includes turn-styles on the defensive end exemplifies that. When you get an entire rotation of guys to buy in on defense, it's special, and that's why we've won 16 in a row. For that reason, the only duo I take over Brown/Tatum is Embiid/Simmons with that caveat that both stay healthy.
Would I trade the duos straight up? I'm not a gambler so no, i wouldn't.