Depends on the pick, but generally, you make that move. And the reason you hesitate is because of what that pick might become (like Simmons, for example), but not because you're giving up crowder.
Crowder will be hard to replace, for sure, but Kevin Love is an elite player at his position. The only things Crowder has over KLove are perimeter defense and physical toughness, but KLove trumps him in rebounding (offensive and defensive), shooting, shot creation, playmaking, and pretty much every other aspect of the game.