Not sure I would. They are just too valuable as trade assets.
I mean, even a number one pick has no guarantees - the guy could could be a superstar, or he might just be a 'very good' player. There's even a chance (a slim chance, but still a chance) that the guy could end up a bust.
Even if he does become a superstar, he might leave after 3 years when the rookie contract expires unless you can add enough complementary talent...tough to do when you've given up all of those draft picks.
I guess if there is a guy in the draft who looks like one of those 'once in a generation' talents then I'd probably do it. But if it's a draft like 2014, then I don't think any of those top guys (Embiid, Wiggins, Parker) are worth that kind of haul. It would have to be a Lebron James / Anthony Davis / Tim Duncan calibre prospect...and I'd still have to think long and hard about it.