This is sad news. Wish him the best!
As far as coming back, I don't doubt that he will. I think what I would be thinking "is it worth it?" Every time he plays he seems to come out with an injury, even minor things. I know people will preach not giving up but I think you can ALWAYS do something else... don't give up on life but choose a different path. It took him a long time to make it back last time because he said something along the lines of caring more about long term health rather than basketball. He's made a fortune, maybe he should try something else or at least take a few years off.
I can't imagine how Kobe's body will feel a few years after retirement, ooh wee, he's going to be in for hell as he gets older.
No matter what he does, I wish him the best. I wouldn't wish this on anyone.