Even though I'm not a football guy, I think that the Manning-Brady one is just silly. Watching Manning lose year after year to the Patriots was like Jordan versus Isiah, until New England downgraded their defense, iirc. I also think that Peyton Manning is the Lebron James of the NFL - he gets all the attention and awards, but when you really look at it, he routinely comes up empty in the biggest games and moments, but again, I don't like football, lol.
Of course, I think that Brady vs Eli Manning is completely one-sided in the favor of the Giants' quarterback, but what do I know?