Building from scratch? I'm going inside/out. Trying to get top notch bigs & go from there.
Otherwise, I probably go Who's route. Establish your core first regardless of position, then build around it accordingly. Not really building for your conference opponents until you get into role players.
Yeah I think that's the way to go too, you can't really dictate what "type" high level talent is available to you most of the time.
Sometimes its Blake Griffin, Anthony Davis, KG, LeBron, etc. Other times its Rose, Brandon Roy, Kyrie, CP3, Deron, etc...
Certainly size is important when looking at overall ceiling.