I like the Astros move to the American league. I think the two leagues needed to be balanced out.
I'm not in love with the idea of having interleague play every week of the season, but it's a necessary evil with an odd number of teams in each league, Didn't baseball deliberately unbalance the leagues when interleague play started, moving Milwaukee to the National League, to avoid that problem?
As for the wildcard, I'm okay with adding another team if the goal is to have a wildcard vs. wildcard "play in" game. I don't want to see things expand past one game, though.
In 1995 when Arizona and Tampa were awarded teams to begin in 1998, MLB didn't want to expand interleauge to year round because it was so new (started in 97) and it wasn't sure if was going to stick around so they had to add 2 teams to the NL for 98 and didn't want them both to be expansion teams. Kansas City was asked first, but it didn't want to move so Milwaukee was asked and it moved from the AL Central to the NL Central. Tampa went into the AL East and the Tigers moved from the AL East to the AL Central.
Now that interleague play is a fixture and it works, it is time to balance the league back out.
but that's just it, I don't think interleague play works at all. I think it stinks. I not a complete purist of the game (I'm not appalled at the use of the DH in the AL) but interleague play should never have been instituted. Takes away from the mystique of the World Series a bit. Then again, as a Brewer fan I've always hated that Selig moved the team to the NL. They don't come to Boston anymore (not that I attend any games anyway since the cancellation of the World Series in '94)
Interleague all season would be horrible. If they're going to ruin the game by failing to keep the leagues separate then they may as well go all the way and just disband the 2 leagues and make one league with 6 divisions and 2 wild card teams make the playoffs. Top record gets the worst wild card in the playoffs.
Oh, and drop the DH completely. Only one style should exist if leagues are merged and too much of the art of the game is lost if the DH is kept.
Northeast: Boston, Yanks, Mets, Washington, Orioles
Mid-Atlantic: Phillies, Pittsburgh, Cleveland, Cincinnati, Detroit
Southeast: Tampa, Marlins, Atlanta, Houston, Rangers,
Midwest: St Louis, Kansas City, Toronto, Cubs, White Sox
MidContinent: Arizona, Colorado, Minnesota, Milwaukee, Mariners,
California: Dodgers, Angels, San Diego, Giants, Oakland
In essense, blow it up and try to develop the local rivalries as much as possible. (Washington-Orioles, NY-NY, CHI-CHI, CLE-CIN, KC-STL, California, Tampa-FLA, Pitt-PHI, HOU-TEX)
In this alignment, the only division that's a stretch for local rivalries is the MidContinent.