I think that a fully healthy, in sync Spurs team could do it. In fact, before the season began I expected them to. Now, I have doubt that they'll have it together in time. Maybe next year, after some retooling in the offseason.
Actually, I think the team with the best shot to do it this year is the Suns. The Lakers have several things that make them great...the outstanding and versatile size up front, elite offensive talents, playoff tested role players that are built for the triangle, and a championship swagger that comes from playing with Kobe and for Phil. With Shaq, Amare, and crazy hair Lopez the Suns have the size and talent to bang with the Lakers up front and win the battle of the paint. With Nash, the Suns have one thing the Lakers aren't built to stop...a penetrating PG that can score and distribute. The Suns also have a squad full of playoff-tested role players, especially on the wings, to throw at Kobe and make him work. And in the playoffs, a team of fossils like the Suns should have the time play big minutes each game then recover in between.
Most importantly, though, Shaq gives the Suns that championship swagger that only Duncan and the Spurs could match when dealing with Kobe. Plus, these teams have history. Shaq and Kobe don't like each other at all. The Suns eliminated the Lakers two straight years before last season. Neither Raja Bell nor Kobe have forgotten Bell clotheslining him and Kobe inviting him into the Octagon. Shaq has to be itching to prove that Bynum isn't in his league. This would, IMO, be a very compelling series that I really hope happens.
Side note: if I could find a prop bet in Vegas on either the Celtics or the Lakers winning 70 this year, I would take it. I wouldn't be surprised if both do, actually. I've long been of the opinion that the Celts could have won 70 last year, but they wanted to save it for the playoffs. The Lakers have a massive chip on their shoulders this year and they're young, so I could see them making a push for 70. And if they do, it could pull the Cs into following suit in the hopes of getting HCA should they meet. I just think that the Lakers and Celtics are head and shoulders above the rest of the league, especially in the regular season, and as such if they focus I don't think either will lose many games this year.